Ceramide, a Sphingolipid Second Messenger.
نویسندگان
چکیده
منابع مشابه
Ceramide: a new second messenger of cannabinoid action.
Cannabinoids, the active components of Cannabis sativa (marijuana), and their endogenous counterparts exert their effects by binding to specific G(i/o)-protein-coupled receptors that modulate adenylyl cyclase, ion channels and extracellular signal-regulated kinases. Recent research has shown that the CB(1) cannabinoid receptor is coupled to the generation of the lipid second messenger ceramide ...
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The physiological role of ceramide formation in response to cell stimulation remains controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling molecule. Recent work points out that the conversion of sphingomyelin into ceramide can play a membrane structural (physical) role, with consequences for membrane microdomain function, membrane vesiculation, fusion/fission a...
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It is now well established that glycerophospholipids and their metabolic products (such as diacylglycerol (DAG), inositol trisphosphate, eicosanoids, and platelet-activating factor) function in signal transduction and cell regulation (14). On the other hand, a role for membrane sphingolipids in signal transduction has not been well appreciated although sphingolipids exhibit even greater structu...
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Apoptosis, also called programmed cell death, is physiologically and pathologically involved in cellular homeostasis. Escape of apoptotic signaling is a critical strategy commonly used for cancer tumorigenesis. Ceramide, a derivative of sphingolipid breakdown products, acts as second messenger for multiple extracellular stimuli including growth factors, chemical agents, and environmental stress...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1994
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.6.278